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Abstract
The objective of this invited review is to describe the introduction and development of the GnRHa trigger protocol in modern IVF, focusing on OHSS prevention and equally important on the role of GnRHa trigger as an opener of the luteal phase “black box”.
GnRHa trigger and freezing of all embryos is the ultimate weapon against OHSS in the OHSS risk patient. In the non OHSS risk patient, GnRHa trigger followed by a modified luteal phase support with LH activity and subsequent fresh embryo transfer results in excellent reproductive outcomes. Thus, GnRHa trigger has paved the way for a virtually OHSS free clinic, and equally important, is the fact that the early lessons learned from studying GnRHa trigger opened the “black box” of the luteal phase enabling improved reproductive outcome in both fresh and frozen embryo transfer cycles.
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Publication history
Accepted:
February 22,
2023
Received in revised form:
December 7,
2022
Received:
September 19,
2022
Publication stage
In Press Accepted ManuscriptFootnotes
Disclosures: PH received unrestricted research grants from MSD, Merck, and Ferring as well as honoraria for lectures from MSD, Merck, Gedeon-Richter, Theramex, Med.E.A and IBSA. TH received honoraria for lectures from Ferring, IBSA, Besins and Merck.
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© 2023 The Authors. Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.
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