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Abstract
Since the first case of 17-alpha-hydroxylase-deficiency (17-OHD) was described in 1966, a number of cases have been reported with a clinical picture of hypertension, hypokalemia, and hypogonadism. Infertility is a major concern for some of these individuals. This mini review aims to detail the components of this disorder that affect fertility and focus on the recent acceleration in success of achieving live births, as well as highlight the unsuccessful attempts. The data supporting successful live births remains limited, but existing evidence suggests that in vitro fertilization (IVF) can be used in conjunction with hormone replacement therapy (HRT) and steroid suppression to achieve live birth in patients with infertility from 17-OHD.
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Publication history
Accepted:
February 24,
2023
Received in revised form:
February 23,
2023
Received:
September 22,
2022
Publication stage
In Press Accepted ManuscriptIdentification
Copyright
© 2023 The Authors. Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.
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