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Objective
To report a case of monozygotic dichorionic twins after a single cryopreserved blastocyst embryo transfer followed by genetic determination of zygosity postpartum.
Design
Case report
Setting
University hospital.
Patients
A 26-year-old female with polycystic ovary syndrome and 36-year-old male partner with severe oligozoospermia resulting in a 1.5-year history of primary infertility.
Interventions
Controlled ovarian stimulation and ICSI treatment with single cryopreserved embryo transfer at blastocyst stage.
Main Outcome Measures
Ultrasound images of the fetuses and short tandem repeat (STR) genotyping postpartum.
Results
Dichorionic twin pregnancy following a single cryopreserved blastocyst embryo transfer was confirmed at the first trimester screening. Confirmatory testing performed postpartum included STR analysis determining monozygosity and pathology examination reporting dichorionic placental configuration.
Conclusions
Dichorionic monozygotic twins are thought to arise from the splitting of an embryo before the blastocyst stage. This case suggests that placental configuration of monozygotic twins may not strictly depend on timing of embryo division. Genetic analysis is the only tool to confirm the zygosity.
Key Words
Article info
Publication history
Accepted:
March 2,
2023
Received in revised form:
March 2,
2023
Received:
December 5,
2022
Publication stage
In Press Accepted ManuscriptFootnotes
Dichorionic twins after blastocyst transfer
Identification
Copyright
© 2023 Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.
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